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What is of-Metalloproteinase-3, Tissue Inhibitor?

A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21 kD, nonglycosylated protein. TIMP-3 does not show a high degree of structural similarity unlike TIMP-1 and TIMP-2 which are structurally similar. However, it does possess a high degree of structural similarity with that of chicken TIMP-3 (ChIMP-3). Human TIMP-3 is of particular concern because of its potential role in cancer, arthritis, and eye diseases.