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What is NAD Transhydrogenase, NADPH?

An enzyme present in the mitochondrial membrane of animals and in microorganisms. In the presence of energy (ATP) it catalyzes reversibly the reduction of NAD by NADPH to yield NADP and NADH. This reaction permits the utilization of the reducing properties of NADPH by the respiratory chain and in the reverse direction it allows the reduction of NADP for biosynthetic purposes. EC 1.6.1.1.